Nicaea was sent by her father to Asia accompanied by her brother Iollas and a certain Archias[1] in 323 BC to be married to the Macedonian military commander, Perdiccas, at a time when Perdiccas still hoped to maintain friendly relations with the regent.
Not so long afterwards, on the advice of Eumenes, Perdiccas decided to divorce Nicaea, so he could marry Cleopatra of Macedon, the full sister of Alexander the Great.
His decision to divorce Nicaea led to an immediate rupture in the relations between Perdiccas and Antipater.
[2] Around 321 BC, as part of an alliance agreement, Antipater married Nicaea to Lysimachus, who governed Thrace.
Nicaea bore Lysimachus three children: one son Agathocles;[4][1] and two daughters: Eurydice[4][1] and Arsinoe I.