[2] Nicaragua qualified one judoka for the women's heavyweight category (+78 kg) at the Games, signifying the nation's return to the sport for the first time since Atlanta 1996.

Izayana Marenco accepted a continental berth from the Americas as the nation's top-ranked judoka outside of direct qualifying position in the IJF World Ranking List of June 28, 2021.

[3] Nicaragua qualified one boat in the men's single sculls for the Games after finishing fourth in the B-final and securing the third of five berths available at the 2021 FISA Americas Olympic Qualification Regatta in Rio de Janeiro, Brazil, marking the country's debut in the sport.

[4][5] An additional slot was awarded to another Nicaraguan rower competing in the women's single sculls, as the nation granted an invitation from the Tripartite Commission and the International Rowing Federation.

Sema Nancy Loudrick topped the list of weightlifters from the Americas in the women's 64 kg category based on the IWF Absolute Continental Rankings.