Niccolò Ardinghelli was born in Florence in 1502, the son of a noble family.
[1] He began his career as a secretary to Cardinal Alessandro Farnese, iuniore.
[1] He was despatched as nuncio to Francis I of France to encourage peace negotiations with Charles V, Holy Roman Emperor and promote support for holding an ecumenical council.
[1] Pope Paul III made him a cardinal priest in the consistory of 19 December 1544.
[1] He received the red hat and the titular church of Sant'Apollinare alle Terme Neroniane-Alessandrine.