He is known for his expressive figures and crowded, action-filled narrative scenes.
He and his workshop later illuminated a variety of other manuscripts, including university texts, choir books and other liturgical texts, private devotional books, and even works of secular poetry and drama.
Niccolò also illuminated a number of specialty books made for various corporate groups in the city, such as statute books and guild registers.
He was a financially successful artist who was appointed illuminator to the city of Bologna in the 1380s and was an active member of city government.
He was the uncle of the artist Jacopo di Paolo (active 1371-1426).