[12] His great-grandaunt was Regina Hesse (1832 –1898), a pioneer educator and school principal who worked with the Basel Mission on the Gold Coast.

[13] His uncle, Theodore S. Clerk (1909 -1965), was the first Ghanaian architect of the Gold Coast who planned and developed the port city of Tema.

[17] He was the cousin of Pauline M. Clerk (1935 - 2013), a diplomat and a presidential advisor[18][19][20] and Alexander Adu Clerk (born 1947), a sleep medicine specialist and psychiatrist[21][22][23][24][25][26][27][28] His granduncle, Emmanuel Charles Quist (1880–1959), a barrister and judge, became the first African President of the Legislative Council from 1949 to 1951, Speaker of the National Assembly of the Gold Coast from 1951 to 1957, and Speaker of the National Assembly of Ghana from March 1957 to November 1957.

[30][31] His other maternal uncle was Nathan Quao (1915–2005), a diplomat, educationist and public servant who became a presidential advisor to the governments of several Heads of State of Ghana.

[1][40] In his early career, he taught English Language and Literature at his alma mater, the Presbyterian Boys Secondary School, Odumase-Krobo, the Government Training College at Peki and Tamale and at the Department of Liberal Arts at the Kwame Nkrumah University of Science and Technology.

[5] The name, "Greenhill", is a reference to the lush greenery and hilly topography of the main campus, as well as its location in Legon which was historically on the periphery of the Ghanaian capital, Accra.

[5] Previously known as the Institute of Public Administration, the school was established in 1961 by the Government of Ghana with financial backing from the United Nations Special Fund Project, for the professional training of the country's civil servants.

[1][4] Furthermore, he performed similar roles in his capacity as a public sector, management and health administration consultant in other African countries including Botswana, Kenya, Liberia, Morocco, Nigeria, Sierra Leone, Tanzania and The Gambia.

[1] Clerk was married and had six children: Carl, Martha, Nicholas Jnr., Pauline, Christine and Caroline, with careers in architecture, corporate management, medicine, finance, public health and nonprofits.

[1] At the dedication of its chapel in 2019, the Grace Presbyterian Church, Nungua-North unveiled a memorial plaque in honour of Nicholas T. Clerk.