The company's Burbank, California branch creates CGI and visual effects for Nickelodeon's animated series.

Soon after its founding in 1994, Nickelodeon Creative Labs introduced an animated mascot consisting of two eyes & a mouth voiced by Chris Phillips for Nick Jr. named Face, who would also often change to a different color and interact with the block’s characters (on-screen and off).

In 1996, Nickelodeon Creative Labs began producing the Nick Jr. series Blue's Clues in-house using Adobe After Effects, Photoshop, and Power Macintosh computers.

The same year, Nick Digital produced the second Backyardigans pilot (featuring the same synopsis as the later episode "The Heart of the Jungle").

The studio used CGI and motion capture, a method that was ultimately rejected by creator Janice Burgess.