Nicolás Federico Spolli (Spanish pronunciation: [esˈpoli], Italian: [ˈspɔlli]; born 20 February 1983) is a retired Argentine professional footballer who played as a defender.

Born in Rosario, Spolli began his youth career with hometown club, Newell's Old Boys.

At the club he was soon a regular in the starting eleven, and by 2009, he made over 100 appearances and also hit the back of the net nearly ten times.

In July 2009, Calcio Catania sporting director, Pietro Lo Monaco confirmed that the Sicilian club were deep into negotiations with Newell's for the defender and on 25 July 2009, the deal was finalized and Spolli officially became a Catania player.

Spolli is currently part of a record-breaking Catania outfit that picked up 56 points from 38 Serie A matches.