[4][5] Blackwood was chosen as the Conservative prospective parliamentary candidate for Oxford West and Abingdon at an open primary on 13 November 2006.

In late 2010, she was elected to serve on the Home Affairs Select Committee and was secretary of the All-Party Parliamentary Group on Overseas Development.

She was a member of the Conservative Party Human Rights Commission,[8] as well as holding a position on the Council of Advisors for ZANE, a charity which seeks to support pensioners in Zimbabwe.

[11][12][13] Blackwood resigned from her ministerial position in the House of Lords in February 2020 to Prime Minister Boris Johnson to pursue time with her family.

[citation needed] At the 2015 general election, Blackwood retained her seat with a majority of 9,582,[15] which was in part due to the national swing of voters against the Liberal Democrats.

[23] Blackwood has been a member of the Conservative Christian Fellowship since 2005, and is a regular worshipper at the Church of England's St Aldate's in Oxford.

[24] Her POTS was thought to be the cause of her fainting in the House of Lords whilst giving a statement at the despatch box on 17 June 2019, although she later said it was "no big deal".