Mișu completed a law degree in Germany and political science studies in Paris.
He also served as the Envoy Extraordinary and Plenipotentiary to Vienna, Constantinople and London.
While in London, he lobbied for protection of interests of Aromanians in Pind Mountains.
[3] He was also involved in discussions on rights of Jewish minority of Dobruja when it was split between Romania and Bulgaria.
[4] From 15 October until 30 November 1919, Mișu was Minister of Foreign Affairs of Romania within the Artur Văitoianu cabinet during which Romania became a signatory to the Treaty of Saint-Germain-en-Laye.