[11] De Santis was recruited by Spencer Stuart from beenz.com in 2001 to become the chief marketing officer of Opodo, the European travel portal originally co-owned with 9 European airlines including British Airways, Air France, Alitalia, Iberia, KLM, Lufthansa, Aer Lingus, Austrian Airlines and Finnair.

[13] De Santis was the marketing director and co-founder of European online travel portal Opodo,[14] a position which he left in 2003.

[19] One of the main activities of the centre was to support the REMAIN campaign in the 2016 United Kingdom European Union membership referendum.

The BRAND EU Centre was launched with the support of former European Parliament President Enrique Baron Crespo and American Investor Todd Ruppert.

[20] De Santis was a board member of Nasdaq-listed Lyris Technologies – a digital marketing & CRM analytic solutions company.

[23] De Santis believes that: "As our planet's population grows exponentially, GVN's role in tackling old and new viruses will become central in preventing, protecting and curing present and future generations.