Prause obtained her doctorate in 2007 at Indiana University Bloomington, with joint supervision by the Kinsey Institute for Research in Sex, Gender, and Reproduction.

Institutional attitudes towards sex research and ongoing safety threats from anti-porn organizations prompted her to found Liberos LLC in 2015.

[citation needed] This is thought to raise new possibilities for intervention for those with high or low sex drive, which could be altered semi-permanently by repeated TBS.

[13] Prause co-authored a study in 2021 on the effects of orgasmic meditation, which concluded that this genital stroking practice increased closeness in partners regardless of whether or not they had an existing romantic relationship.

[14] Prause has appeared in media education about sexual science, including: PBS Nova Secret Lives of Scientists,[15] the Today show's Brain power series,[16] and After Porn Ends 2.