After appearing in several video clips, van Dam got the role of the conceited Bionda in the kids soap ZOOP, which was aired on the Dutch Nickelodeon.

Van Dam also appeared in the movies Deuce Bigalow: European Gigolo and Plop in de Stad, dubbed a voice in Ice Age: The Meltdown and had a guest role in one of the most successful investigation series of the Netherlands; Baantjer.

On 18 June 2014, during the 2014 FIFA World Cup, Nicolette van Dam tweeted a photo-shopped mock-up of Colombia national team members James Rodríguez and Radamel Falcao snorting vanishing foam with the caption "Colombian wall", making an allusion of snorting cocaine.

Colombian Minister of Foreign Affairs María Ángela Holguín spoke out against Van Dam, saying "This is not the first time that she has put out a disparaging tweet, and Colombia will not accept this".

[2] Holguín proceeded to request Colombian ambassador in the Netherlands, Eduardo Pizarro Leongómez, to go to the chancellery of said country in search for more severe consequences to Van Dam's "disrespect towards Colombia".