A plaque on the facade commemorates that the poet Adam Oehlenschläger died in the building on 20 November 1840.

Other notable former residents include the naval officer Steen Andersen Bille, Tivoli Gardens-founder Georg Carstensen, medical doctor Ole Bang, diplomat and minister H. E. Reedtz (1800-1857), politician Christian Albrecht Bluhme (1794-1866), General Christian de Meza (1792-1865) and politician Aleth Hansen.

The property was marked on Christian Gedde's 1757 cadastral map of St. Ann's East Quarter as No.

He resided in the building with his second wife Anne Elisabeth Juel and their 24-year-old son Ove Christian Haxthausen at the 1801 census.

At the 1834 census, Frederikke Vilhelmine Charlott Bille (née Bornemann, 1770-1851) resided in the building with her granddaughter Frederike Marie Levetzau, three male servants and three maids.

He lived there with his wife Juliane Andrea Christensen (née Holst) and their six children (aged three to 14).

[5] Ulrik Nicolai Fugl (1807-1867), a military prosecutor, notarius publicus in Copenhagen and later bank manager of Privatbanken, resided on the third floor with his wife Henriette Caroline Augusta Fugl (née Moe, 1719-1761), their six children, a nanny, a male servant and a maid.

Aleth Hansen, who had recently served as Minister of Education, lived briefly in the building in 1870.

[9] Shortly after World War II, Amaliegade 22 was acquired by publisher Valdemar Richter-Friis (1896–1976).