The Nieuwe Prinsengracht is a canal in the Plantage neighborhood of Amsterdam, an extension of the Prinsengracht in the eastern Grachtengordel (canal belt).

The Nieuwe Prinsengracht runs between the Amstel and the Plantage Muidergracht.

It is connected to Onbekendegracht, which runs behind the Royal Theater Carré, and is crossed by Weesperstraat and Roetersstraat.

Until 1866 the Nieuwe Prinsengracht ran east of the Muidergracht to the Entrepotdok.

The three ponds within the Artis zoo site still remain from the filled-in section of the canal.