[6][7][8] De Jager first began uploading videos to YouTube in 2008, at the age of 14, after watching MTV's The Hills while sick and being inspired by Lauren Conrad's makeup.

[10] In the autumn of 2013, she became the head makeup artist for the RTL 5 show I Can Make You a Supermodel with Paul Fisher.

[10][12] De Jager left Colourfool Agency at the beginning of 2014 to work as a freelance hair and makeup artist.

The brand stated in a press release that "in this newly created role, Nikkie will be integrated into the brand’s product development process, as well as share her incredible talent and expertise to expand unique content and artistry around the world on both Marc Jacobs Beauty and her own channels.

[29] In August 2020, De Jager launched her own eyeshadow palette in collaboration with the brand Beauty Bay.

[30] On 13 January 2020, De Jager shared YouTube video titled "I'm Coming Out", in which she publicly came out as transgender.

In January 2019, she participated in the nineteenth season of the popular Dutch reality game show Wie is de Mol?.

After her coming-out video became popular in January 2020, De Jager was a guest on The Ellen DeGeneres Show, where she talked about her experience coming out as transgender.

[42][43] On 10 February 2020, it was announced that De Jager would be the online host of the Eurovision Song Contest 2020, which was planned to be held in Rotterdam.