Philotheos Skoufos, Elias Moskos, and Theodore Poulakis were all active painters on the Ionian Islands prior to Kallergis.

His mother's name was Helena and his father was famous painter and priest Fragiskos Kalergis.

The local Metropolitan Priest Iosef Doksas bequeathed the Church of Saint Anna of Zakynthos to his father.

Famous Cretan poet Marino Tzanes discussed the Kallergis family in his writing.

Historical documentation regarding Nikolaos is dated from 1744 regarding a painting in the Church of Faneromenis in Zakynthos.

Kallergis takes us into the late-Baroque or Rococo during the Modern Greek Enlightenment in art also known as Neo-Hellenikos Diafotismos.