From 2005 to 2019 Knoepffler was chair of the Ethics Commission of the Department of Social and Humanistic Studies, University of Jena.
He is a member of the Bavarian Ethics Committee and the Preimplantation Genetic Diagnosis Commission at the Landesärztekammer Baden-Württemberg [de].
He was a principal investigator (2012-2018) in the trilateral project "Hearts of Flesh - not Stone", funded by the DFG, that included scholars from Israel, Palestine and Germany.
Knoepffler speaks in academic and popular contexts on topics related to his field of ethics.
"[4] His research specialties include bioethics, human dignity, conflict management, business ethics, leadership, and German philosophy.