Non-CPU (AI and AI-S) lenses are supported, but only Manual and Aperture-Priority exposure programs are available, using centre-weighted metering.
Autofocus is not supported with AF-I and AF-S lenses, and Vibration Reduction (VR) is not available regardless of the lens.
The F-801 continued the trend established by earlier Nikon cameras such as the F-301/N2000 and F-501/N2020 in not being provided with an ISO-standard cable release socket.
It had improved autofocus performance and incorporated spot metering, but retained the original model's reputation for reliability.
During the early 1990s, the F-801s sat at the top of the company's consumer range of autofocus cameras, which also included the F-401 and F-601.