He usually portrayed a poor man, hit hard by fate, seeking justice or one struggling against wealthy and evil men.

Films included: Ο Αετός των Σκλαβωμένων (The Eagle of the Enslaved) and Είμαι μια δυστυχισμένη (I am a miserable girl).

Martha Vourtsi and Xanthopoulos, quickly became a duo, starring in seven films, their most notable being Περιφρόνα με γλυκιά μου (Contempt me, my dear).

Other actresses that played the love interest of Nikos Xanthopoulos were: Angela Zilia, Afroditi Grigoriadou, Kakia Analyti, Katerina Vasilakou, Mairoula Evangelou, Dora Sitzani and Kaiti Papanika.

Xanthopoulos starred in 48 movies from 1958 to 1971: His most notable films are: Adiki Katara, Kapote Klaine Kai Oi Dynatoi, I Kardia Enos Aliti, O Katatregmenos, I Odysseia Enos Xerizomenou, Sklavoi Tis Moiras, Tapeinos Kai Katafronemenos, Ftohogeitonia Agapi Mou and Perifrona me Glykeia Mou.