In 1910, the Blues played their only season as charter members of the short–lived Class D level Indiana-Michigan League, hosting home games at LaPierre Park.
The Berrien Springs Grays, Dowagiac, Michigan team, Elkhart Blue Sox, Gary Sand Fleas and Ligonier, Indiana team joined the Niles Blues as charter members in league play.
[5][4] Reportedly, Marshall hired Guy Morton to pitch a game for Niles when the team was without a pitcher.
[1][6][2] When the Indiana–Michigan League permanently folded on August 21, 1910, the Niles Blues were in third place with a 8–10 record, playing under manager Fred Marhsall.
[5] The player rosters and statistics for the 1910 Indiana-Michigan League teams, Niles included, is unknown.