Her first record production was titled Ninel Conde (2003), which contains the song "Callados", played a duet with singer José Manuel Figueroa.

Her role as Alma Rey in Rebelde (2004–2006) expanded her career to Chile, Romania, Colombia, Brasil, Peru, Spain, Croatia.

Conde began appearing on the American dramedy series Ugly Betty where she portrays an actress on a "faux" telenovela that is seen by the main character's family.

In 2008, she played the character Rosario Montes in Fuego en la sangre alongside Adela Noriega and Eduardo Yañez, was nominated by the participating TVyNovelas Award as "Best actress co-star."

In 2012 participates in the soap opera Porque el amor manda as Discua Paz De La Soledad.