The show stars Anahí, Dulce María, Alfonso Herrera, and Christopher von Uckermann, with Maite Perroni in her debut role, and Christian Chávez.

[4] The adult protagonists are Juan Ferrara and Ninel Conde, in a stellar performance, with Enrique Rocha and Tony Dalton portraying the antagonists.

Due to its school setting, it contains an ensemble cast, including Angelique Boyer, Estefanía Villarreal, Karla Cossío, Zoraida Gómez, Jack Duarte, and Eddy Vilard.

Another notable aspect of the show is that the actors playing the band members are themselves in an actual group named RBD and perform most of the music used on the telenovela, including the opening theme song, "Rebelde".

The group achieved international success from 2004 until their separation in 2009 and sold over 15 million records worldwide, making them one of the best-selling Latin music acts of all time.

However, few even graduate since they are persecuted by a secret society called "La Logia" ("The Lodge"), whose purpose is to conserve the purity of the privileged class.

Among the students are Mía Colucci Cáceres (Anahí), Roberta Pardo Rey (Dulce María), Miguel Arango Cervera (Alfonso Herrera), Diego Bustamante (Christopher von Uckermann), Guadalupe "Lupita" Fernández (Maite Perroni) and Giovanni Méndez López (Christian Chávez).