Nispen (Brabantian dialect: Nipse) is a town in the Dutch province of North Brabant.

Gaining some wealth by the trade in turf, the village was destroyed during the Eighty Years' War.

Following the Peace of Münster Nispen has been on both the national and religious borders between Protestant Netherlands and Catholic Belgium.

The stream Bansloot between Nispen and the Belgian village of Essen forming the border.

[3] Earliest human activity around Nispen, as shown by a stone tool, dates from around 7,000 BCE.

At Rozenakker remains are located of a Roman farm dated around the year 150 CE.

[3] The first mention of the name Nisipa dates from a certificate from 1157 in which Henry II of Leez, prince-bishops of Liège, confirmed gifts made by Arnulf and his son Arnulf II to Tongerlo Abbey which had the right of patronage of the parish of Nispen.

[3] After World War I Franciscan sisters from Roosendaal started the Saint Antonius monastery in Nispen with an attached girls school.

During World War II Nispen suffered German bombardments as it was located near a railroad.

In memory of the 22 villagers who died during the war the Peace Chapel (Dutch: Vredeskapel) was built in 1946.