[1][2] Yoshioki was the second son of Nitta Yoshisada (1301–1338), who supported the Southern Court of Emperor Go-Daigo and Kamakura from the Hōjō clan in 1333.

[1] Yoshioki aided his father in the siege of Kamakura in 1333, and battled alongside Kitabatake Akiie.

[1] Returning to the countryside of Kozuke and Musashi provinces, Yoshioki continued to fight for some time before being captured by Takezawa Nagahira.

[2] He was sentenced to death by the minister of Motouji, Hatakeyama Kunikiyo, and was executed at the age of 28 by drowning in the Tama River at Yaguchi in present-day Ōta ward of Tokyo.

Yoshioki is the subject of an Edo-period kabuki play by Hiraga Gennai (1728–1780) titled Shinrei Yaguchi no Watashi.