The album includes guest appearances from Khalid, Camila Cabello, Cardi B, Chance the Rapper, PnB Rock, Stormzy, Yebba, Justin Bieber, Travis Scott, Eminem, 50 Cent, Young Thug, J Hus, Ella Mai, Paulo Londra, Dave, H.E.R., Meek Mill, A Boogie wit da Hoodie, Skrillex, Chris Stapleton, and Bruno Mars.

Further released singles were "Cross Me", "Beautiful People", "Blow", "Best Part of Me", "Antisocial", "South of the Border", and "Take Me Back to London".

The sixth single, "Take Me Back to London", which features British rapper Stormzy, was sent to UK radio airplay on 9 August 2019.

[19] In a positive review, Alexis Petridis of The Guardian wrote that "unsurprisingly, the end result sounds not unlike a Top 20 rundown or Spotify's Hot Hits UK playlist" and that "Sheeran succeeds in pulling off his patent trick of simultaneously stunning you with the pitiless commercial efficiency of his writing while retaining a certain ordinary-bloke humanity," naming the album "smarm, charm and a watertight winning formula.

"[20] Similarly, Neil McCormick of The Daily Telegraph says, "Sheeran has delivered a solid commercial showcase of the power of contemporary pop music brands.

"[22] In a more mixed review, Helen Brown, writing for The Independent concluded that "though his fare is bland, it is sincere and hygienically prepared.

[23] Stephen Thomas Erlewin of AllMusic called pointed out Sheeran's "blandiness" but complimented him for knowing "that this is the sound that defines global pop in 2019" and the fact that the album was full of multiple genres.

"[24] Writing for Rolling Stone, Danny Schwartz opined that "Sheeran's unobtrusively sweet voice easily slips between genres, but he struggles to connect with many of his A-list guest artists, deepening the album's isolated mood.

"[27] Malvika Padin of Clash called the record "worth a listen to catch those glimpses of experimentation" but felt that some songs "feel out of place and fail to impress despite the involvement of such acclaimed artists.

"[28] Lucy Shanker of Consequence of Sound wrote that "Sheeran has got the pop-song formula down pat" and that "he's versatile, or at least trying to be" but that "it doesn't pay off, though, because this effort results in a sense of emptiness, an abyss of authenticity or real feeling.

"[30] Michael Cragg of The Observer called the record "a hotchpotch of genres and guests a laser-guided exercise in streaming monopoly, a credibility-by-osmosis playlist primed for summer dominance.

6 Collaborations Project debuted at number one on the US Billboard 200 with 173,000 album-equivalent units (AEUs), including 70,000 pure album sales.

[44] The album debuted at number one in other 14 countries, including Australia, New Zealand, Ireland, Taiwan, Norway, Sweden, Belgium, the Netherlands and Finland.