Raised for service during the Second World War, the squadron was equipped with Consolidated Liberator aircraft and carried out operations against the Japanese during the Burma campaign.

The squadron was formed at Salbani, Bengal, British India on 18 August 1943, and carried out its first bombing mission on 20 November 1943.

[3] The squadron mounted numerous raids on the Burma–Siam railway along with other important targets such as bridges, airfields, port facilities, supply dumps, gun positions, and marshalling yards.

[6][7] Wing Commander James Brindley Nicolson, recipient of the only Victoria Cross awarded during the Battle of Britain, was killed 2 May 1945, when the 355 Squadron Liberator he was flying in as an observer, crashed into the Bay of Bengal shortly after an engine caught fire.

Between January and April 1946 the squadron operated from Digri, a little north of Salbani,[8] returning to Salbani (west of Calcutta) where it undertook aerial survey work shortly before it disbanded on 31 May 1946.