No Friendly Drop is a 1931 mystery detective novel by the British writer Henry Wade.

[1] It was the second in a series of seven novels featuring the character of Inspector Poole, published during the Golden Age of Detective Fiction.

[2] It was released in the United States the following year by Brewer and Warren where it received positive reviews in the New York Herald Tribune and the New York Evening Post, with the latter describing it as "A superior detective story, depending more upon intrinsic interest in a logical plot than upon excitement and goriness for its hold on the reader".

When Lord Henry Grayle is found dead in bed his country house it is at first assumed he committed suicide by taking an overdose of sleeping pills.

However, a more detailed examination reveals traces of scopolamine in his body creating a fatal combination of the two drugs.