Klinglesmith, Albert Rennie and several other businessmen forded the South Canadian River and laid claim to the 160-acre (65 ha) town site that was to become Noble.

The town was named in honor of Secretary of the Interior John Noble, who was instrumental in opening the Unassigned Lands to settlement.

For several years, Noble was a major shipping point for cattle and other goods from both sides of the Canadian River.

Business prospered even more when Charles Edwin Garee built a new suspension toll bridge across the Canadian River in 1898.

Local geologist Joe Stine and his wife opened the Timberlake Rose Rock Museum in 1986 and closed it in 2019.

It is bordered to the north by Norman, to the east by Slaughterville, and to the west by the Canadian River, across which is McClain County.

The Noble Public Schools' district (Independent #40 as numbered by the state) covers a huge area, stretching west to east across south-central Cleveland County between Norman and Little Axe school districts to the north and Lexington's to the south.

Pioneer formerly educated sixth graders; however, they now attend the recently completed Noble Middle School.

The schools' athletic programs compete in Oklahoma's class 5A in most sports, including football, basketball, baseball, and golf.

Noble High is also home to many clubs, programs and extra-curricular activities, such as a class 5A marching band under the direction of Fred Queen, or BotBall led by Cole, which earned the Rookie Team Award at GCER 2019.

Over the decades since the district and High School grew to their modern size in the 1970s, various programs in newspaper, yearbook, vocal music, Student Council, FFA and others have held statewide office and been leaders in their fields.

This means that students come from the north half of Slaughterville as well as Noble and unincorporated areas, and even a strip of rural south Norman.

Formally dating to only 1970, the Town of Slaughterville never carved out its own school district, and its residents' children attend either Noble, Lexington, or are home-schooled.