[3] NoV has been found to multiply in several insect and tick species; however, these infected individuals seem to be asymptomatic.

Nodamura virus is the only member of the genus Alphanodavirus that can infect insects, fish, and mammals.

[2] The virion is organized in T=3 icosahedral symmetry, which means there are 60 triangular subunits each made up of 3 viral capsid proteins.

Studies have shown that B2 proteins help to repress an antiviral response in nodamura infected cells.

[5] The nodamura virus protein B2 (encoded by RNA3) has been shown to modulate the host process of antiviral response.

[8] Since nodamura virus infects insects, fish, and mammals, there are different diseases caused in different species.

[5] In wax moth larvae and honey bees, nodamura virus has been found to cause paralysis.

Suckling mice and hamsters that have been inoculated with nodamura virus showed paralysis in their limbs, followed by death.

In Aedes albopictus and Toxorhynchites amboinensis mosquitoes, nodamura virus induced a loss of balance and an inability to fly.