He authored several works on Georgian literature, including the medieval epic poet Shota Rustaveli, as well as Thomas Aquinas and the problems of national culture.
In July 1989, he became a founding member and chairman of the political group Popular Front, which called for independence and a gradual transition to a market economy fearing it would lead to foreign firms seizing Georgian national resources.
In August 1989, through the efforts of the influential group of intellectuals DASi (Democratic Choice for Georgia), Natadze was elected to the Supreme Soviet of the Georgian SSR as a member of the anti-Communist opposition.
In Georgia's first multi-party legislative election in 1990, Natadze succeeded in securing a seat in the Supreme Soviet in a single-mandate constituency despite his party gaining only 1.9% of the vote.
[5] After Gamsakhurdia was ousted in a military coup in January 1992, Natadze was a member of the newly convened Parliament of Georgia on a party ticket of the election bloc Eleventh of October from 1992 to 1995.