The district is bounded by other Bangkok districts (from north clockwise): Thawi Watthana, Bang Khae, Bang Bon of Bangkok, Krathum Baen of Samut Sakhon province, Sam Phran and Phutthamonthon of Nakhon Pathom province.

That is why many local important places such as temples, communities, markets and police station located along the canal.

On July 15, 1904, it was low tide while the royal barge went through Nong Khaem via Khlong Phasi Charoen.

The King did stay in front of Wat Nong Khaem temple, a local spiritual anchor.

During the flood season, locals used rowing boats for up to the waterfront market of Wat Nong Khaem.

Nong Khaem is known for its abundant plantings of canna in the centre median strip of Phet Kasem Road.

In 1973 Thai President Foods started production of MAMA brand instant noodles in a factory in Nong Khang Phlu.

Two other Bangkok Metropolitan Administration (BMA) disposal centres are on the east side of the river, in Prawet and Sai Mai districts.