Neighbouring districts are (from the north clockwise): Ratchathewi, Huai Khwang, Suan Luang, Phra Khanong, Khlong Toei, and Pathum Wan.

Watthana became a separate district by splitting from Khlong Toei in 1998 to provide better service to its population.

The district obtained its name from Princess Galyani Vadhana, the elder sister of King Bhumibol Adulyadej.

Encompassing the area between Sukhumvit Road and Khlong Saen Saep, Watthana is one of the commercial districts in Bangkok, with many condominiums and hotels.

The golden rays of light extending from the roof of the pavilion are said to symbolise her divine grace to all Thais.