The district is bounded by other Bangkok districts (from north clockwise): Thawi Watthana, Bang Khae, Bang Bon of Bangkok, Krathum Baen of Samut Sakhon province, Sam Phran and Phutthamonthon of Nakhon Pathom province.

On July 15, 1904, it was low tide while the royal barge went through Nong Khaem via Khlong Phasi Charoen.

The King did stay in front of Wat Nong Khaem temple, a local spiritual anchor.

Nong Khaem is known for its abundant plantings of canna in the centre median strip of Phet Kasem Road.

[2] The old building of Nong Khaem Police Station more than 100 years old, located on the Khlong Phasi Charoen.

In 1973 Thai President Foods started production of MAMA brand instant noodles in a factory in Nong Khang Phlu.

Nong Khaem is the original location of Channel 3, before moving to the current Khlong Toei district in 1999.

Two other Bangkok Metropolitan Administration (BMA) disposal centres are on the east side of the river, in Prawet and Sai Mai districts.