In 2012, Arnezeder appeared in the American action thriller film Safe House, portraying the girlfriend of Ryan Reynolds' character.

In 2013, she was the leading actress in the period drama adventure film Angélique directed by Ariel Zeitoun.

She appeared as Chloe Tousignant, a French intelligence investigator, in the main cast of the first two seasons (2015–17) of the CBS series Zoo.

[8] In 2021, Arnezeder played Lilly "The Coyote" in Zack Snyder's Netflix film Army of the Dead.

[10] She starred in the 2021 English-language German-Swiss science fiction thriller film Tides (The Colony), playing the lead role of Blake.