Norman–Roberts syndrome is a rare form of microlissencephaly caused by a mutation in the RELN gene.

The syndrome was first reported by Margaret Grace Norman and M. Roberts et al. in 1976.

[2] Lack of reelin prevents normal layering of the cerebral cortex and disrupts cognitive development.

[citation needed] Norman–Roberts syndrome is one of two known disorders caused by a disruption of the reelin-signaling pathway.

The other is VLDLR-associated cerebellar hypoplasia, which is caused by a mutation in the gene coding for one of the reelin receptors, VLDLR.