This is caused by the profound underdevelopment of the mouse's cerebellum, a segment of the brain responsible for locomotion.
In the reeler neocortex, cortical plate neurons are aligned in a practically inverted fashion ("outside-in").
[1] In the dentate gyrus of hippocampus, no characteristic radial glial scaffold is formed and no compact granule cell layer is established.
[2] Therefore, the reeler mouse presents a good model in which to investigate the mechanisms of establishment of the precise neuronal network during development.
[17] In the later years, histopathological studies revealed that the reeler cerebellum is dramatically decreased in size and the normal laminar organization found in several brain regions is disrupted (Hamburgh, 1960).