It serves the Lowell Line, and is located in the North Billerica village.

The depot building, built in 1867, was renovated, expanded, and returned to station use in 1998.

In 1998, the North Billerica Depot underwent extensive renovations as part of the Massachusetts Bay Transportation Authority's efforts to restore and expand its Billerica commuter rail stop.

On January 23, 2015, several people were injured when the retractable edge of the outbound platform collapsed while passengers were deboarding.

Media related to North Billerica station at Wikimedia Commons