North Carolina Highway 110 (NC 110) is a 5.51-mile-long (8.87 km) primary state highway in the U.S. state of North Carolina.

The route serves to connect the rural communities of Cruso, Woodrow, and Bethel with the town of Canton entirely in Haywood County NC 110 begins at the intersection of US 276 and NC 215 south of Canton.

The road continues to run through a semi rural area until it reaches the town of Canton.

Once reaching Canton the road continues to follow Pisgah Drive but makes a sharp left turn in the center of the city, as it reaches its northern terminus.

Shortly after the creation of the road US 70 was assigned to the entire length of the highway.