North Carolina Highway 481 (NC 481) is a 21-mile (34 km) primary state highway in the U.S. state of North Carolina, connecting Enfield to nearby Interstate 95 (I-95) and the surrounding farmlands of southern Halifax County.

NC 481 is a two-lane rural highway that serves primarily as a farm-to-market route[citation needed] rather than as one to destinations other than Enfield.

It begins at an intersection with NC 4/NC 48 in the community of Glenview, then proceeds east, quickly connecting with I-95 along the way.

After passing through town, it splits with US 301 north of Enfield and continues northeasterly.

NC 481 made three brief appearances before the routing that exists today.