North Carolina Highway 461 (NC 461) is a primary state highway in the U.S. state of North Carolina.

Its western terminus is at NC 561, passes through Winton and Cofield, and has its eastern end at an entrance to a Nucor steel plant east of Cofield.

From Winton, and in concurrency with NC 45, it travels through Cofield, then splits just east of the village.

It continues north on Farmers Chemical Road, then east on River Road, ending at the entrance of Nucor Plate Mill, Hertford.

[2] In 1999, NC 461 was extended east, with a short concurrency with US 13 it splits near Winton, where it follows along Old Highway 13 to NC 45, then in concurrency until Farmers Chemical Road, where it continues as a new primary spur to the steel plant.