Primarily in the Piedmont Triad, it runs from NC 109 in Thomasville northeast to the Virginia state line in Milton.

East of Archdale, it overlaps with NC Bike Route 2 through the communities of Climax and Julian.

In 1933, the route was moved north of New London and extended to Mount Pleasant.

The last change to the route was between 1954–57, between the community of Fitch to Yanceyville, moving to a new road east; leaving behind Oak View Loop Road and Badgett Sisters Parkway.

[2] Historically there was one 3-mile-long (4.8 km) alternate route in New London, from 1935-1940; it was labeled as NC 62A.