North Carolina Highway 57 (NC 57) is a 43.1-mile-long (69.4 km) primary state highway in the U.S. state of North Carolina and a semi-rural traffic artery connecting Roxboro to a few small-to-medium-sized towns in The Triangle region north of the cities of Durham and Chapel Hill.

It heads northeast through Orange County, passing through Schley and intersecting NC 157 in Caldwell.

The route crosses into Person County and then runs concurrent with US 501 heading north through Timberlake and Somerset.

It continues to the northwest and then it enters Milton before reaching its northern terminus at the intersection with NC 62.

During the 1920s, NC 57 originally ran east–west from Roxboro to Henderson along present day US 158.