On its routing from Thomasville to Stokesdale, NC 68 passes through urban High Point, the western outskirts of Greensboro, and the town of Oak Ridge.

The segment from just north of the I-40/US 421 interchange to Pleasant Ridge Road in Guilford County is a limited access freeway.

Approximately one mile (1.6 km) within the city limits, NC 68 turns left onto Westchester Drive, a boulevard that bypasses High Point's downtown area.

After passing Oak Hollow Mall, I-74 (High Point East Belt), and the Wendover Avenue interchange, NC 68 and Eastchester Drive continue north into neighboring Greensboro.

[9][10] In 1952, NC 68 was extended north to its current terminus with the then new US 220 bypass, replacing part of old US 220 (Sylvania Road).