U.S. Route 220 (US 220) is a north–south U.S. highway which travels from Rockingham, North Carolina, to South Waverly, Pennsylvania.

The highway is an important north–south route in Central North Carolina, connecting Rockingham, Asheboro, Greensboro, and Summerfield.

[2] Immediately north of the bridge, US 220 intersects US 74 Business (Broad Avenue) and runs west of downtown Rockingham.

The highway makes a gradual turn to the northwest, crosses Little Carr Creek, and exits Rockingham to the north.

North of downtown, US 220 diverges slightly to the northwest at an intersection with East Main Street.

US 220 travels through central Norman on McLeon Avenue and intersects Moore Street in the center of the town.

[1][3] Entering into rural southern Randolph County, I-73, I-74, and US 220 makes a slight turn to the northwest to bypass Seagrove to the east.

The highways run adjacent to Randolph Community College and several government buildings which are located off the McDowell Road exit.

From the Presnell Street interchange, the highway begins to travel away from downtown Asheboro but largely runs west of the city limits.

Immediately north of the interchange, I-73 and US 220 cross underneath a railroad owned by the Norfolk Southern Railway.

[2] I-73 and US 220 interchange with Academy Street west of downtown Randleman, and several commercial businesses are located off of the exit.

The highway makes a sweeping curve to the northwest as it travels north of the interchange and enters into a rural area of Randolph County.

It utilizes a partial causeway and bridge to cross Randleman Lake immediately following the curve.

The highway then bypasses the community to the west and crosses into Guilford County approximately 2.0 miles (3.2 km) north of the US 220 Business interchange.

[1][3] Entering into Guilford County, the highway increasingly travels through suburban regions south of Greensboro.

US 220 continues travelling north-northwest along the freeway for 0.3 miles (0.48 km) before meeting I-40 at an interchange, where it follows I-40 to the east.

The highway travels through an industrial region of Greensboro before interchanging with Martin Luther King Jr. Drive and O'Henry Boulevard.

A quadrant interchange with Bessemer Avenue is located at the northeastern corner of the North Carolina A&T State University campus near Truist Stadium.

US 220 continues west of the creek for 0.6 miles (0.97 km) until diverging northeast onto Battleground Avenue at an interchange.

It parallels a former railroad line of the Atlantic and Yadkin Railway to the east for approximately 0.3 miles (0.48 km) between Pembroke Road and Lawndale Drive.

US 220 continues northwest for 1.3 miles (2.1 km) before meeting I-73 at an incomplete interchange, with a northbound freeway entrance and a southbound exit.

[1][3] Continuing north into Rockingham County, I-73 and US 220 travel for approximately 1 mile (1.6 km) before meeting NC 65 at a diamond interchange, exit 122.

From the interchange, US 311 begins running concurrently with US 220 to the north for 2.5 miles (4.0 km), crossing the Dan River east of downtown Madison.

As it continues north of Stoneville, US 220 primarily travels through a forested region with some sporadic farmland.

An interchange with Smith Road is located 2.4 miles (3.9 km) north of NC 770 and US 220 begins to run parallel to its former alignment and the Norfolk Southern railroad it crossed southwest of Stoneville.

A final at-grade intersection with Martinsville Loop is located 0.2 miles (0.32 km) south of the North Carolina-Virginia state line.

Also, at some point during the decade, US 220 was extended south to its current terminus with US 1, leaving behind Ellerbe Road in Rockingham.

[5][6] On January 7, 2008, US 220 was moved onto new freeway between Emery to south of Ellerbe, leaving its old alignment another extension of US 220 Alternate.

Currently all right-of-way purchases have been completed along the proposed route, with construction beginning in 2012 on upgrading US 220 north of Rockingham.

The remaining sections of the new bypass is currently scheduled to begin construction in late 2017; however, it is subject to reprioritization.