[6] Several of the pioneers who migrated across the midwest to claim a part of Symmes' tract are buried in North College Hill's oldest landmark, the LaBoiteaux-Cary cemetery.

Established in approximately 1806, the cemetery includes the graves of two Revolutionary War veterans and several members of the Cary family.

Robert called the land Clovernook Farm and initially erected a small frame house for his family.

In 1832, he built the white, brick house now known as Cary Cottage (see photo) which stands on the campus of the Clovernook Center for the Blind and Visually Impaired and is listed on the National Register of Historic Places.

[10] Within a year of his settlement, Robert also laid out the first community in the area, called Clovernook, on the east side of Hamilton Avenue.

Both girls began having their poems published as teenagers, and they eventually counted among their admirers Massachusetts poet and abolitionist John Greenleaf Whittier, New York Tribune newspaper editor Horace Greeley, and author Edgar Allan Poe, who pronounced Alice Cary's Pictures of Memory, "one of the most musically perfect lyrics in the English language".

The sisters used the land to establish the Clovernook home and provide employment to visually impaired women as a source of dignity and direction.

Today, the Clovernook Center for the Blind and Visually Impaired offers instruction, employment, community living and low vision services for men and women, and runs three manufacturing departments, including one of the world's largest volume producers of Braille publications.

[12] In the latter part of the nineteenth century, North College Hill was the home of Dr. Isaac Mayer Wise, who has been called “the most prominent Jew of his time in the United States”[13] for his influence as one of the early leaders of Reform Judaism in America.

In 1861, Wise and his wife Therese bought a house and 42-acre (170,000 m2) farm near the current intersection of Goodman and Hamilton Avenues, where they raised a family of ten children.

[17][18] Ohio law allowed small towns like North College Hill to operate "liquor courts".

[19] In Tumey v. Ohio (1927), the U.S. Supreme Court ruled the Crabbe Act was unconstitutional as financial conflicts of interest impaired the right to a fair trial.

Beginning in 1905, saw mill owner John Meyer used his surplus lumber to build a subdivision of small homes north of Galbraith Road and west of Hamilton Avenue and called it Meyerville.

[7] As the automobile stretched commuting distances, the village's affordable housing attracted a growing population, and it increased from about 1,100 to 4,100 residents during the 1920s.

[23] A few homes were removed for the completion of Ronald Reagan Cross County Highway (Ohio State Route 126) in 1997.

[26] On November 6, 2007 a ballot initiative to make North College Hill a charter city was passed by the voters.

[27] In 2011 North College Hill was rated the "best place to raise kids in Ohio" by Bloomberg Businessweek, based on such factors as school performance, the number of schools, crime statistics, cost of living, job growth, air quality, ethnic diversity, and access to recreational facilities.