North Dome stands within the watershed of the Hudson River, which drains into New York Bay.

The northern slopes of North Dome drain into the West Kill via Hagadone Brook and Bennett Brook, thence into Schoharie Creek, the Mohawk River, and the Hudson River.

The southern slopes of North Dome drain into Esopus Creek, and thence into the Hudson River.

North Dome is contained within the Westkill Mountain Wilderness Area of New York's Catskill State Park.

The only way to the top of the North Dome is through private land, a nearby summer camp.