It is adjacent to The O2 (originally the Millennium Dome) at the northern end of the Greenwich Peninsula, on the south bank of the Thames, and is the easternmost below-ground station on the line.

An Underground station was first proposed for the Greenwich Peninsula in a government report on the redevelopment of London's Docklands published in 1973.

A station was originally planned at Blackwall north of the river, but the line was diverted between Canary Wharf and Stratford underneath the Thames to serve the Greenwich peninsula.

[12] In 1996, Greenwich was chosen as the site for the Millennium Experience, with the under construction station considered to be a key part of the transport infrastructure.

[20] North Greenwich is one of the largest stations on the Jubilee line, capable of handling around 20,000 passengers an hour, having been designed to cope with the large number of visitors expected at the Millennium Dome (now The O2 Arena).

The striking blue-tiled and glazed interior, with raking concrete columns rearing up inside the huge underground space, was designed by the architects practice Alsop, Lyall and Störmer.

[23] The IFS Cloud Cable Car opened nearby on 28 June 2012, providing a link between the Greenwich Peninsula and the Royal Victoria Dock and ExCeL London.