The professional staff includes approximately seventy-five full-time teachers, a library/media coordinator, an academic support center coordinator, four guidance counselors, three school nurses, a school psychologist, approximately fifteen teaching assistants, two assistant principals, one principal, and a resource officer.

The citizens of the neighboring town of Mason, New Hampshire expressed an interest in possibly joining the North Middlesex District in 2006.

Prior to its first day in use, a bomb threat was received, necessitating the presence of the Townsend, MA police department with metal detectors.

The North Middlesex Tri-M Music Honor Society students also run Stars@Symphony, a two-day event that takes place at Mechanics Hall (Worcester, MA) and Symphony Hall (Boston, MA) which showcases bands that receive gold medal ratings from the Massachusetts Instrumental and Choral Conductors Association.

[5] North Middlesex Regional High School hosts many athletic teams which compete in the Midland Wachusett league(Mid-Wach).