It serves the communities of North Syracuse, Clay, Cicero, Bridgeport, and Mattydale.

The District covers 89 sq mi (230 km2) with approximately 5,600 residents.

[3] The North Syracuse Central School District is the largest of the 23 component school districts in the Onondaga-Cortland-Madison (OCM) Boards of Cooperative Educational Services (BOCES).

As a component of the OCM BOCES, NSCSD participates in its career and technical, alternative and special education programs.

The current logo was designed by then Junior Joseph Byrns (class of 95) in a computer graphics course at Cicero-North Syracuse High School.