Northampton left the Downs on 12 March 1741, bound for China.

On the return leg of her voyage she traversed the Bocca Tigris on 31 December, reached the Cape on 13 April 1742, and St Helena on 25 May.

[2] The Indiamen Northampton, Queen Caroline, Halifax, Royal George, Kent, Scarborough, and snow Swift left St Helena on 26 June, together with their escorts, HMS Argyl and HMS Lynn.

[2] Northampton left the Nore on 20 July 1744, bound for Bombay and China.

She was in company with Hardwick, but they parted during a violent storm about 50 leagues east of Bourbon.